Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity
نویسندگان
چکیده
منابع مشابه
Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity.
The focus of this research was to develop a better understanding of the pertinent physico-chemical properties of silver nanoparticles (AgNPs) that affect genotoxicity, specifically how cellular uptake influences a genotoxic cell response. The genotoxicity of AgNPs was assessed for three potential mechanisms: mutagenicity, clastogenicity and DNA strand-break-based DNA damage. Mutagenicity (rever...
متن کاملIn vivo Genotoxicity of Silver Nanoparticles after 90-day Silver Nanoparticle Inhalation Exposure
OBJECTIVES The antimicrobial activity of silver nanoparticles has resulted in their widespread use in many consumer products. Yet, despite their many advantages, it is also important to determine whether silver nanoparticles may represent a hazard to the environment and human health. METHODS Thus, to evaluate the genotoxic potential of silver nanoparticles, in vivo genotoxicity testing (OECD ...
متن کاملCarbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
BACKGROUND Increasing use of silver nanoparticles (Ag-NPs) in various products is resulting in a greater likelihood of human exposure to these materials. Nevertheless, little is still known about the influence of carbohydrates on the toxicity and cellular uptake of nanoparticles. METHODS Ag-NPs functionalized with three different monosaccharides and ethylene glycol were synthesized and charac...
متن کاملGenotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel
BACKGROUND Since silver-nanoparticles (NPs) possess an antibacterial activity, they were commonly used in medical products and devices, food storage materials, cosmetics, various health care products, and industrial products. Various silver-NP based medical devices are available for clinical uses, such as silver-NP based dressing and silver-NP based hydrogel (silver-NP-hydrogel) for medical app...
متن کاملAcute toxicity and genotoxicity of silver nanoparticle in rats
OBJECTIVE The potential risk of a nanoparticle as a medical application has raised wide concerns, and this study aims to investigate silver nanoparticle (AgNP)-induced acute toxicities, genotoxicities, target organs and the underlying mechanisms. METHODS Sprague-Dawley rats were randomly divided into 4 groups (n = 4 each group), and AgNP (containing Ag nanoparticles and released Ag+, 5 mg/kg)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mutagenesis
سال: 2015
ISSN: 1464-3804,0267-8357
DOI: 10.1093/mutage/gev020